"Parkour wanker!" Instant classic.
NPC 1: "Well this is much better than Renaissance Italy, at least I don't have to put on a really bad accent."
NPC 2: "I work for Belethor at the General Goods store. I also seem to be in the wrong game."
NPC 3 (as Connor does an Air Assassination): "Na na na na na na na na BATMAAAAAAN!"
NPC 4: "I totally thought that bit at the theatre at the beginning was Lincoln's assassination, didn't you?"